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DHEA levels are directly related to mortality (the probability of dying) in humans. In a 12-year study of over 240 men aged 50 to 79 years, researchers found that DHEA levels were inversely correlated with mortality, both from heart disease and from all causes. This finding suggests that DHEA level measurements can become a standard diagnostic predictor of disease, mortality and lifespan. Furthermore, if animal results hold true, supplemental DHEA may prevent disease, reduce mortality, and extend lifespan in humans.
DHEA is known to be a precursor to the numerous steroid sex hormones (including estrogen and testosterone) which serve well-known functions. Although the specific mechanisms of action for DHEA are only partially understood, supplemental use of CELLFOOD® DHEA has been shown to have anti-aging, anti-obesity and anti-cancer influences. In addition, it is known to stabilize nerve-cell growth and is being tested in Alzheimer's patients. DHEA and Cancer Early reports from England [Bulbrook, 1962, 1971] suggested that DHEA was abnormally low in women who developed breast cancer, even as much as nine years prior to the onset or diagnosis of the disease. Of the 5000 women followed in the study, 27 developed cancer. Most of the 27 had abnormally low levels of DHEA. Many years later, Dr. Arthur Schwartz of Temple University found that supplemental DHEA significantly protected cell cultures from the toxicity of carcinogens. Cell cultures usually respond to powerful carcinogens with mutations (changes in DNA), transformations (changes in cell appearance), and a high rate of cell death. But when Schwartz added DHEA along with the carcinogen, all three of these effects were significantly diminished. DHEA and Glucose Metabolism Investigators have shown that DHEA inhibits glucose-6-phosphate dehydrogenase (G6PDH), an enzyme that breaks down glucose. There are two glucose-metabolizing pathways in the body, the catabolic, energy-yielding pathway and the anabolic, biosynthetic pathway. G6PDH happens to be the first enzyme in the biosynthetic pathway, the one which results in the synthesis of fatty acids and ribose (the sugar used in making deoxyribonucleic acid, or DNA). In simple language, G6PDH turns glucose into fat. DHEA and Aging The body's production of DHEA drops from about 30 mg at age 20 to less than 6 mg per day at age 80. According to Dr. William Regelson of the Medical College of Virginia, DHEA is "one of the best biochemical bio-markers for chronologic age." In some people, DHEA levels decline 95% during their lifetime - the largest decline of an important biochemical yet documented. DHEA levels are directly related to mortality (the probability of dying) in humans. In a 12-year study of over 240 men aged 50 to 79 years, researchers found that DHEA levels were inversely correlated with mortality, both from heart disease and from all causes. This finding suggests that DHEA level measurements can become a standard diagnostic predictor of disease, mortality and lifespan. Furthermore, if animal results hold true, supplemental DHEA may prevent disease, reduce mortality, and extend lifespan in humans. DHEA: The Buffering Steroid? DHEA may be unique among hormones for it's lack of specificity for hormone receptor sites. Just as vitamin E has never been shown to have a specific metabolic role (it is only proven essential as a general antioxidant), DHEA may serve an equally general purpose. "DHEA is the first example of a buffer action for hormones that I know of," states William Regelson. "It is a broad-acting hormone that only demonstrates itself under a specific set of circumstances. In that way, it is like a buffer against sudden changes in acidity or alkalinity. That is why when you get older, you're much more vulnerable to the effects of stress. As DHEA declines with age, you are losing the buffer against the stress-related hormones. It is the buffer action that [helps prevent] us from aging." The decrease of DHEA with age may result in gradual decline of a system for suppressing enzyme systems responsible for creating the building blocks of new cells, like lipids, nucleic acids (RNA and DNA) and sex steroids. The resulting rise in enzymatic activity in advanced age may be responsible for the proliferative events (cancer) and degenerative disease that become more frequent in advanced age. In this respect, DHEA might be best considered to be an anti-hormone, which might "de-excite" steroid-sensitive receptors that would otherwise lead to enhanced metabolic activity. Hormones derived from animals or from synthetic sources have been in common use in the treatment of various illnesses. DHEA, or dehydroepiandrosterone, has been the focus of interest lately with its supposed positive effect on the aging process, weight loss, heart disease, Alzheimer's disease, AIDS, lupus and cancer. Production of DHEA begins during fetal development and stops at birth. Hormone secretion resumes at about age seven, and peaks at thirty. However, studies yielded contradictory or inconclusive results with regards to its effect on the aging process. One researcher, Dr. Elizabeth Barret-Connor of University of California at San Diego School of Medicine, noted that the incidence of heart disease in those with high blood levels of DHEA was lower. Follow up studies on the same patients over a longer period, however, did not show the same results. Dr. Barret-Connor expressed some reservations about the beneficial effects of DHEA and was even surprised at the fact that a number of physicians have been using it on patients, despite the lack of objective data. A few preliminary studies have shown that DHEA prevents the development of breast cancer in mice and even improved the animal's immune system. Women taking DHEA have shown a drop in their cholesterol blood level. In a small study, DHEA is said to improve energy levels and immunity. DHEA is converted into other hormones in the body. It is not understood whether these are direct effects of the hormone, or effects of other hormones synthesized from DHEA in the body. DHEA used to be marketed in health food stores as a weight loss promoter, although the FDA has directed stores to stop selling it as such until the drug is proven safe and effective. On the other hand, one study has shown that DHEA was linked to the development of liver cancer in mice and led to an increased insulin resistance, growth of unwanted hair, and a drop in HDL (good) cholesterol. Hormones can affect the body in a number of ways and, even with intensive clinical testing, results of hormonal therapy can sometimes be surprising. Please, we do not sell
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